
You've likely come across something called hyaluronic acid. It is one of the trendiest ingredients on drugstore shelves today. Hyaluronic acid (HA) is a naturally occurring substance in the body, including the skin and the vaginal tissue. It is known for its moisturizing and hydrating properties, which can benefit vaginal dryness and discomfort. It effectively delivers moisturizing benefits without irritating. It's a common ingredient in moisturizers, anti-aging products, and supplements.
Some of the most exciting developments in hyaluronic acid research are the revolutionary ways HA locks in moisture in the vagina. A key player in tissue regeneration, hyaluronic acid's job is to retain water to keep our tissues moist and well-lubricated.
HA vaginal products are available in gels, creams, and suppositories. These products are typically available over the counter and do not require a prescription. We tried multiple products on the market. Unfortunately, most over-the-counter products do not specify how much HA they contain. You could have a product manufactured with the exact amount of HA at your local compounding pharmacy, but you will need a prescription.
Is Hyaluronic Acid Safe to Use Vaginally and Internally?
Yes. Products with HA are easy to use and can be applied vaginally as needed. Researchers found that hyaluronic acid’s hydrating capabilities make it an ultra-effective treatment to relieve vaginal dryness. Women of any age, who experience vaginal dryness, benefit from the regular use of a moisturizer with this ultra-soothing ingredient.
Are you concerned about allergies or interactions with your body? Since the body naturally produces hyaluronic acid, allergic reactions are rare. Regarding ratings for cancer, developmental and reproductive toxicity, and immunotoxicity concerns, hyaluronic acid is listed as "low."
It is important to note that while HA is generally considered safe, it is always best to consult with a healthcare provider before using any new products or treatments. Some women might have allergies and sensitivities to HA, so it is essential to test the product on a small area of the skin before using it vaginally.
If you don't want to use a vaginal moisturizer with estrogen, products with hyaluronic acid can be a great alternative. Or it could be used to supplement your estrogen vaginal cream.
Remember, if you're looking to update your intimate care regimen, it's important to slowly introduce these types of products and observe the difference they make. Once you've fully integrated it into your daily routine, you'll likely start noticing all the benefits hyaluronic acid offers — and telling your friends about its advantages.
Stay tuned for our HA products, made in Florida and from pure natural ingredients, coming soon!
The only guide you will need to choose the perfect vaginal moisturizer.

Renata's Ultimate Guide to Vaginal Moisturizers.
We tested 30+ vaginal moisturizers on the US market. We used them for 4 to 8 weeks to appreciate immediate and long-term satisfaction. We evaluated seven different categories:
a/ effectiveness
b/ price
c/ ease of use
d/ feel
e/ ease of purchase
f/ side effects, and
g/ we also asked our sexual partners about their feedback.
We rated each category from 1 to 5 stars, 1 being the worst and 5 being the best, with the best possible total score being 35.
Disclaimer:
We did not receive any financial or any other support from developers, manufacturers, sellers, or distributors of the products we tested.
And the Top 10 Winners are:
#10. With 25 points
Silicone Lube KY liquibeads Ovule Inserts
a/ effectiveness 1 star (not meant to be a vaginal moisturizer, effects are not lasting)
b/ price 5 stars (reasonable price)
c/ ease of use 3 stars (possibly needs applicator, messy and oily)
d/ feel 3 stars (oily)
e/ ease of purchase 5 stars (Amazon)
f/ side effects 4 stars (does not help to maintain proper pH)
g/ sexual partner feedback 4 stars (oily taste, suitable as a lubricant)
#9. With 26 points
VH Essentials Vaginal Odor Treatment with Vitamin C vaginal suppositories
a/ effectiveness 1 star (not meant to be a vaginal moisturizer, effects are not lasting)
b/ price 5 stars (reasonable price)
c/ ease of use 3 stars (possibly needs applicator, quickly dissolves and trickles out)
d/ feel 3 stars (watery, needs to be used before bedtime)
e/ ease of purchase 5 stars (Amazon)
f/ side effects 5 stars (boric acid suppository which supports proper pH)
g/ sexual partner feedback 4 stars (waxy taste, just ok as lubricant)
#8. With 27 points
Carlson Key-E Suppositories
a/ effectiveness 2 stars (just ok as a moisturizer, effects are not lasting)
b/ price 5 stars (reasonable price)
c/ ease of use 3 stars (possibly needs applicator, quickly dissolves and trickles out)
d/ feel 3 stars (waxy, leaves a waxy residue on bed sheets)
e/ ease of purchase 5 stars (Amazon)
f/ side effects 5 stars (does not seems to disturb the pH, has added vitamin E)
g/ sexual partner feedback 4 stars (waxy taste, just ok as lubricant)
#7. (tie between 6 and 7) With 29 points
Vagisil Prohydrate Internal Vaginal Moisturizer
a/ effectiveness 3 stars (advertised to last three days, but it doesn't)
b/ price 4 stars (reasonable price)
c/ ease of use 3 stars (weird pointy applicator)
d/ feel 5 stars (natural, not oily)
e/ ease of purchase 5 stars (Local Pharmacy, Walmart, Amazon)
f/ side effects 5 stars (does not seems to disturb the pH)
g/ sexual partner feedback 4 stars (neutral taste, just ok as lubricant)
#6. (tie between 6 and 7) With 29 points
Replens Long-Lasting Vaginal Moisturizer
a/ effectiveness 3 stars (advertised to last 3 days, but it doesn't)
b/ price 4 stars (reasonable price)
c/ ease of use 3 stars (weird pointy applicator)
d/ feel 5 stars (natural, not oily)
e/ ease of purchase 5 stars (Local Pharmacy, Walmart, Amazon)
f/ side effects 5 stars (does not seems to disturb the pH)
g/ sexual partner feedback 4 stars (neutral taste, just ok as lubricant)
#5. (tie between 4 and 5) With 30 points
Bezwecken Hydratation Ovals 2x Plus DHEA
a/ effectiveness 4 stars (no added Hyaluronic acid, enhanced with estriol and DHEA)
b/ price 4 stars (small size of ovals, might need repeated applications)
c/ ease of use 5 stars (discrete, no applicator or refrigeration required)
d/ feel 4 stars (natural, not oily)
e/ ease of purchase 5 stars (Amazon)
f/ side effects 5 stars (does not seem to disturb proper pH, contains small amounts of estriol)
g/ sexual partner feedback 3 stars (cocoa butter smell and taste, not enough lubrication)
#4. (tie between 4 and 5) With 30 points
Good Clean Love Restore, pH balancing, and moisturizing vaginal gel
a/ effectiveness 3 stars (no Hyaluronic acid)
b/ price 5 stars (affordable pack of four)
c/ ease of use 4 stars (needs applicator)
d/ feel 4 stars (occasionally feels sticky)
e/ ease of purchase 5 stars (Local Pharmacy, Amazon)
f/ side effects 5 stars (maintains natural pH)
g/ sexual partner feedback 4 stars (not enough lubrication)
#3. With 31 points
HA (hyaluronic acid) vaginal suppositories (compounding pharmacy)
a/ effectiveness 5 stars (added Hyaluronic acid 5 or 10 mg)
b/ price 5 stars (cheaper than Revaree suppositories))
c/ ease of use 4 stars (needs refrigeration, quality varies between pharmacies)
d/ feel 5 stars (natural, not oily)
e/ ease of purchase 3 stars (Compounding pharmacy, needs a prescription)
f/ side effects 5 stars (does not seems to disturb the pH)
g/ sexual partner feedback 4 stars (slightly waxy taste, loved the effect on their own skin)
#2. With 32 points
Revaree suppositories
a/ effectiveness 5 stars (added Hyaluronic acid)
b/ price 4 stars (overpriced, compounding pharmacies suppositories are less expensive but need a prescription)
c/ ease of use 4 stars (needs refrigeration in hotter climate))
d/ feel 5 stars (natural, slightly waxy)
e/ ease of purchase 5 stars (on their website or Amazon)
f/ side effects 5 stars (does not seems to disturb the pH)
g/ sexual partner feedback 4 stars (slightly waxy taste, loved the effect on their own skin)
#1. With 33 points
Good Clean Love Bionourish, ultra-moisturizing vaginal gel with hyaluronic acid
a/ effectiveness 5 stars (added Hyaluronic acid)
b/ the price 4 stars (overpriced)
c/ ease of use 4 stars (needs applicator)
d/ feel 5 stars (natural, not oily)
e/ ease of purchase 5 stars (Amazon)
f/ side effects 5 stars (maintains proper pH)
g/ sexual partner feedback 5 stars (neutral taste, loved the effect on their own skin)
In a world where the price would not be an issue, the vaginal lubricant with the best effectiveness and long-lasting effects was a combination of these two products:
Good Clean Love Bionourish, ultra-moisturizing vaginal gel with hyaluronic acid and Revaree suppositories.
In my quest for clarification of the balance of risks and benefits of hormone therapy options for menopause symptoms, I came across this MenoNote recently created by NAMS. MenoNotes are free information sheets written by menopause experts that provide clear, easy-to-understand explanations of important menopause-related topics. This valuable handout simplifies the data in the 2022 Hormone Therapy Position Statement. NAMS grants permission to healthcare professionals to reproduce this MenoNote for distribution to women in their quest for good health.
It's a short 5 minutes read, but it covers most of the questions you might have. I highly recommend reading it.

Deciding About Hormone Therapy Use Many women experience hot flashes, vaginal dryness, and other physical changes with menopause. For some women, the symptoms are mild and do not require any treatment. For others, symptoms are moderate or severe and interfere with daily activities. Hot flashes improve with time, but some women have bothersome hot flashes for many years. Menopause symptoms often improve with lifestyle changes and nonprescription remedies, but prescription therapies also are available, if needed. Government-approved treatments for bothersome hot flashes include hormone therapy (HT) containing estrogen, as well as a nonhormone medication (paroxetine). Hormone therapy involves taking estrogen in doses high enough to raise the level of estrogen in your blood in order to treat hot flashes and other symptoms. Because estrogen stimulates the lining of the uterus, women with a uterus need to take an additional hormone, progestogen, to protect the uterus. Women without a uterus just take estrogen. If you are bothered only by vaginal dryness, you can use very low doses of estrogen placed directly into the vagina. These low doses generally do not raise blood estrogen levels above postmenopause levels and do not treat hot flashes. You do not need to take a progestogen when using only low doses of estrogen in the vagina. (The MenoNote “Vaginal Dryness” covers this topic in detail.) Every woman is different, and you will decide about whether to use HT based on the severity of your symptoms, your personal and family health history, and your own beliefs about menopause treatments. Your healthcare professional will be able to help you with your decision. Potential benefits Hormone therapy is one of the most effective treatments available for bothersome hot flashes and night sweats. If hot flashes and night sweats are disrupting your daily activities and sleep, HT may improve sleep and fatigue, mood, ability to concentrate, and overall quality of life. Treatment of bothersome hot flashes and night sweats is the principal reason women use HT. Hormone therapy also treats vaginal dryness and painful sex associated with menopause. Hormone therapy keeps your bones strong by preserving bone density and decreasing your risk of osteoporosis and fractures. If preserving bone density is your only concern, and you do not have bothersome hot flashes, other treatments may be recommended instead of HT. Potential risks As with all medications, HT is associated with some potential risks. For healthy women with bothersome hot flashes aged younger than 60 years or within 10 years of menopause, the benefits of HT generally outweigh the risks. Hormone therapy might slightly increase your risk of stroke or blood clots in the legs or lungs (especially if taken in pill form). If started in women aged older than 65 years, HT might increase the risk of dementia. If you have a uterus and take estrogen with progestogen, there is no increased risk of cancer of the uterus. Hormone therapy (combined estrogen and progestogen) might slightly increase your risk of breast cancer if used for more than 4 to 5 years. Using estrogen alone (for women without a uterus) does not increase breast cancer risk at 7 years but may increase risk if used for a longer time. Some studies suggest that HT might be good for your heart if you start before age 60 or within 10 years of menopause. However, if you start HT further from menopause or after age 60, HT might slightly increase your risk of heart disease. Although there are risks associated with taking HT, they are not common, and most go away after you stop treatment.
Potential adverse events
Hormone therapy can cause breast tenderness, nausea, and irregular bleeding or spotting. These adverse effects are not serious but can be bothersome. Reducing your dose of HT or switching the form of HT you use often can decrease adverse effects. Weight gain is a common problem for midlife women, associated with both aging and hormone changes. Hormone therapy is not associated with weight gain and may lower the chance of developing diabetes.
Hormone therapy options
Each woman must make her own decision about HT with the help of a healthcare professional. If you decide to take HT, the next step is to choose between the many HT options available to find the best dose and route for you. With guidance from your healthcare professional, you can try different forms of HT until you find the type and dose that treats your symptoms with few adverse effects.
Pill or non-pill
Hormone therapy is available as a daily pill, but it also may be taken as a skin patch, gel, cream, spray, or vaginal ring. Non-pill forms may be more convenient. Hormone therapy pills need to be taken every day, but skin patches are changed only once or twice weekly, and the HT vaginal ring is changed only every 3 months. Hormone therapy taken in non-pill form enters your blood stream more directly, with less effect on the liver. Studies suggest that this may lower the risk of blood clots in the legs and lungs compared with HT taken as a pill.
Estrogen alone or estrogen plus progestogen
If you have a uterus, you will need to take progestogen with your estrogen. Many pills and some patches contain both hormones together. Otherwise, you will need to take two separate hormones (eg, estrogen pill with progestogen pill or estrogen patch with progestogen pill). Taking both hormones every day usually results in no bleeding. Women who prefer regular periods can take estrogen every day and progestogen for about 2 weeks each month. Another option is to take estrogen combined with a nonhormone medication (bazedoxifene) to protect the uterus. If you do not have a uterus, you can take estrogen alone, without a progestogen.
Dose of estrogen
As with all medications, you should take the lowest dose of estrogen that relieves your hot flashes. You can work with your healthcare professional to find the right dose for you. It typically takes about 8 to 12 weeks for HT to have its full effect, so doses should be adjusted slowly. Even low doses of estrogen will preserve your bone density and reduce your risk of a fracture.
Stopping hormone therapy
There is no “right” time to stop HT. Many women try to stop HT after 4 to 5 years because of concerns about potential increased risk of breast cancer. Other women may lower doses or change to non-pill forms of HT. Hot flashes may or may not return after you stop HT. Although not proven by studies, slowly decreasing your dose of estrogen over several months or even over several years may reduce the chance that your hot flashes will come back. You and your healthcare professional will work together to decide the best time to stop HT. If very bothersome hot flashes or night sweats return when you stop HT, you will need to reassess your individual risks and benefits to decide whether to continue HT. Because there may be greater risks with longer duration of use and as you age, you and your healthcare professional will work together to decide what is the best option for you.
This MenoNote, developed by the NAMS Education Committee of The North American Menopause Society, provides current general information but not specific medical advice. It is not intended to substitute for the judgment of a person’s healthcare professional. Additional information can be found at www.menopause.org.
Copyright © 2022 The North American Menopause Society. All rights reserved. NAMS grants permission to healthcare professionals to reproduce this MenoNote for distribution to women in their quest for good health.
Made possible by donations to the NAMS Education and Research Fund.